Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data

Data characterizing a panel of biodegradable cross-linked polyester implants for sustained delivery of an anti-viral drugMendeley Data

Blog Article

Tenofovir alafenamide (TAF) is currently administered orally to patients for treatment flexcon reverse osmosis water storage tank of chronic hepatitis B virus infection and as a part of a combination therapy for human immunodeficiency virus (HIV) infection.A long-acting delivery system could provide several advantages as a formulation strategy for this drug including improved patient adherence, convenience, more consistent drug levels and potentially fewer side effects.To date, the vast majority of polymer-based long-acting delivery systems have been prepared from poly(lactide-co-glycolide) [1].To expand the range of polymers available for use, cross-linkable allyl functionalized, polyester copolymers were considered for preparation of disc-shaped, implantable delivery systems for TAF.

The physico-chemical properties of the implants were evaluated including thermal and spectral properties as well as in vitro stability.Subsequently the discs were loaded with TAF via a swelling-equilibrium approach and the discs were further characterized including, TAF loading and in vitro drug release.This dataset shows the potential of here using these polymeric materials as a sustained delivery platform for TAF.The dataset is freely available on Mendeley Data.